Formulated to optimize antioxidant levels in the macula, providing protection from oxidative stress and optimizing visual performance

Carotenoids: Lutein, Meso-zeaxanthin and Zeaxanthin are known as macular pigments. These pigments are uniquely located in the center area of the retina called the macula.5, 6 The macula is responsible for processing our crisp, clear high-definition vision used for reading, driving and to see colors. It requires more oxygen to function than any other tissue in the body1, therefore extremely susceptible to oxidative stress and damage.

Carotenoids are potent antioxidants to help protect our vision throughout life. In addition to their antioxidation capability, carotenoids are dichroic filters that selectively allow green, yellow and red wavelengths to pass through them while reflecting blue light. This function not only reduces photooxidative stress but also plays an important role in optimizing our vision.7 For example enriching macular pigment results in a reduction in glare disability, improved contrast sensitivity, faster critical flicker fusion and a reduction in photostress recovery times.7, 8

Algae Oil: Rich in high quality omega-3 fatty acid called Docosahexaenoic Acid (DHA). The retina has a high concentration of omega-3’s, particularly DHA, which optimizes fluidity of photoreceptor membranes, retinal integrity, and visual function. Furthermore, many studies demonstrated that DHA has a protective, for example antiapoptotic, role in the retina.2

Bilberry: Contains anthocyanins which are plant-based polyphenols that have shown potent antioxidant and anti-inflammatory activities. Antioxidants play an important role in the prevention and treatment of age-related ophthalmic diseases; whose pathogeneses involve oxidative stress and inflammation.3

Astaxanthin: A powerful antioxidant, astaxanthin has been found to increase blood flow around the eye.9

Vitamin E: Mixed blend of delta and gamma isomers. Vitamin E is a strong antioxidant that provides protection and support to many of our organs. In the eye, Vitamin E helps protect it from UV light.4

References:

  1. Mahabadi, N., Khalili, Y. A., Neuroanatomy, Retina; NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.
  2. Querques, G., et. al., Retina and Omega-3, Journal of Nutrition and Metabolism Volume 2011, Article ID 748361, 12 pages doi:10.1155/2011/748361
  3. Bungau S., et. al., Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases; Oxidative Medicine and Cellular Longevity Volume 2019, Article ID 9783429, 22 pages https://doi.org/10.1155/2019/9783429
  4. Schilling R., Health Benefits of Vitamin E Tocotrienols; Review of Dr Barrie Tan’s presentation at the 26th Anti-Aging Conference of the American Academy of Anti-Aging Medicine in Las Vegas (Dec 13-15, 2018)
  5. Snodderly et. al., The Macular Pigment II Spatial Distribution in Primate Retina’s; Investigative Ophthalmology and Vision Science, 1984 Vol 25
  6. Landrum, J., Bone, R., Mini Review: Lutein, Zeaxanthin and the Macular Pigment; Archives of Biochemistry and Biophysics, 385, No. 1, January 1, pp. 28–40, 2001
  7. Stringham, J., et. al., Macular Carotenoid Supplementation Improves Visual Performance, Sleep Quality, and Adverse Physical Symptoms in Those with High Screen Time Exposure; Foods 2017. 6, 47; doc10.3390/foods6070047
  8. Stringham, J., Garcia, P., et. al., Macular Pigment and Visual Performance in Glare: Benefits for Photostress Recovery, Disability Glare, and Visual Discomfort; IOVS September 2011, Vol. 52, No. 10
  9. Nagaki Y., et. al., The Effect of Astaxanthin on Retinal Capillary, Blood Flow in Normal Volunteers; Journal of Clinical Therapeutics and Medicines Vol. 21, No. 5 (May) 2005

Formulated to promote age-related eye health

This formulation is designed to reduce risk of progression from intermediate stage dry age-related macular degeneration to the advanced wet stage of the disease as shown in the results of the NIH funded AREDS studies. 1

Zinc: Known as the “Essential Toxin”,2 Zinc plays a critical role in our health including supporting our immune system and promoting wound healing among other benefits.2 The NIH recommends a daily intake of 11mg for adult men and 8mg per day for adult women. The AREDS & AREDS2 studies both used 80mg of zinc per day to see if it had any impact on reducing the progression to advanced age-related macular degeneration.  In the AREDS2 study, two cohorts, one receiving 80mg of zinc and the other receiving 25mg of zinc showed no clinically significant difference in disease progression.3

Vista Advanced AREDS2 is formulated with a safer level, 25mg of zinc which is lower than the 40mg per day maximum allowance as defined by the NIH. The AREDS2 study showed patients receiving 80mg per day doses of zinc for an average of 6.3 years had significant increases in hospitalizations for genitourinary causes, raising the possibility that chronically high intakes of zinc adversely affect some aspects of urinary physiology.3

Selenium: An essential trace mineral selenium is necessary for proper thyroid and immune system functioning. In the eye, Selenium promotes Vitamin E absorption and has been shown to slow the progression of eye symptoms related to Graves’ Disease4, an autoimmune condition affecting the thyroid. In diabetics, selenium may play a vital role in the prevention of diabetic retinopathy.5

L-Glutathione: An enzyme that helps protect the eye against chemical and oxidative stress. In the lens and cornea, Glutathione contributes to the transparent and refractive properties which are essential for image formation on the retina.6 In the cornea glutathione plays a role in maintaining normal hydration levels, and, in protecting corneal integrity.6

AREDS and AREDS2 are registered trademarks of The U.S. Department of Health and Human Services (HHS). Jun 16, 2016

References:

  1. Chew E.Y, et.al. Secondary Analyses of the Effects of Lutein/Zeaxanthin on Age-Related Macular Degeneration Progression AREDS2 Report No. 3; JAMA Ophthalmology Published online December 5, 2013
  2. Plum et.al., The Essential Toxin: The Impact of Zinc on Human Health; Int. J. Environ. Res. Public Health 2010, 7, 1342-1365; doi:10.3390/ijerph7041342
  3. National Institute of Health (NIH) Zinc Health Professionals Fact Sheet; Updated July 15, 2020 https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/
  4. Zheng et.al., Effects of Selenium Supplementation on Graves’ Disease: A Systematic Review and Meta-Analysis, Evidence-Based Complementary and Alternative Medicine Volume 2018, Article ID 3763565
  5. Gonzalez de Vega et.al. Protective effect of selenium supplementation following oxidative stress mediated by glucose on the retinal pigment epithelium, https://pubmed.ncbi.nlm.nih.gov/29119175/
  6. Ganea, E., Harding, J., Glutathione – related enzymes and the eye, Current Eye research 2006 Jan;31(1): 1-11

Formulated to promote moist, healthy tears

GLA & Omega-3: Omega-3 and 6 fatty acids play an integral role in the body’s ability to regulate and balance inflammation.

Supplementation with gamma-linolenic acid (GLA) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) has been found to decrease the production of disease-relevant inflammatory mediators that are implicated in the pathogenesis of chronic dry eye.1

Hyaluronic Acid: Found naturally in our cells, Hyaluronic Acid plays a key role in the repair and healing of the corneal epithelium.2

Lactoferrin: Found naturally in our tears, it has anti-inflammatory effects and promotes cell growth.  Patients with chronic dry eyes have low levels of lactoferrin in their tear film which accounts for the typical redness and soreness experienced by those with dry eye syndrome.3

Astaxanthin: A powerful antioxidant, astaxanthin has been found to increase blood flow around the eye.4

Eyebright: An Herb used in traditional herbal medicine for centuries, particularly for minor eye ailments like redness and irritation.5


References:

  1. Sheppard JD Jr, Singh R, McClellan AJ, et al. Long-term Supplementation With n-6 and n-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial. Cornea. 2013;32(10):1297-1304. doi:10.1097/ICO.0b013e318299549c
  2. Carlson E., et. al., Impact of Hyaluronic Acid-Containing Artificial Tear Products on Reepithelialization in an In Vivo Corneal Wound Model; JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS Volume 34, Number 4, 2018, DOI: 10.1089/jop.2017.0080
  3. Devendra J., Singh S. Effect of Oral Lactoferrin on Cataract Surgery Induced Dry Eye: A Randomized Controlled Trial, Journal of Clinical and Diagnostic Research, October, 2015.
  4. Nagaki Y., et. al., The Effect of Astaxanthin on Retinal Capillary, Blood Flow in Normal Volunteers; Journal of Clinical Therapeutics and Medicines Vol. 21, No. 5 (May) 2005
  5. https://www.healthline.com/nutrition/eyebright